Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity
GP and GS, containing diverse glycosyl groups, selectively stimulate specific gut bacteria, triggering mechanisms involved in SCFA-GLP-1/PYY signaling and IGN activation to reduce adiposity in HFD-fed mice. The study enhances understanding of the chemical components crucial for the gut microbiota-mediated anti-obesity effect of ginseng. The mechanistic understanding provides valuable insights for developing ginseng-based drugs or health products to combat obesity.
Authors
- Caixia Dong (ORCID: https://orcid.org/0000-0002-4749-9510)
- Wei-Hao Zhang
- Jun Xu (ORCID: https://orcid.org/0000-0002-9541-6388)
- Yui-Man Chan
- Kam-Chun Chan
- Song‐Lin Li (ORCID: https://orcid.org/0000-0003-1354-7729)
- Jing Fang (ORCID: https://orcid.org/0009-0002-2517-9329)
- Han-Yan Luo
- Aiping Lyu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Hong Kong Baptist University (HK)
- Chinese University of Hong Kong (HK)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.jare.2024.12.002
- Citations
- 20
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Hong Kong Government