PHARMACOKINETICS AND PHARMACODYNAMICS OF EPINEPHRINE WITH ARTERIAL RECEPTORS DURING ADAPTATION TO COLD BY THE LINEWEAVER-BURK AND SKETCHARD METHOD

Based on the study of the data of hourly monitoring of total peripheral vascular resistance (TPVR) in 33 children with ARF, the revealed increase in TPVR by more than two times with a hyperdynamic type of hemodynamics remained increased during intensive care, hemodialysis in all patients.A significant direct correlation of TPVR and DBP was observed only in patients of the 1st group.The most prolonged inversion of the circadian rhythm of the TPVR was detected in the 2nd group (16 days out of 30), somewhat less long in the children of the 3rd group (12).