Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction
We derived and validated predictive models incorporating clinical and endothelial biomarkers to identify pediatric patients with septic shock at high risk of persistent acute respiratory dysfunction. Pending prospective validation, such models may facilitate enrichment and targeted intervention in future clinical trials.
Authors
- Jane Whitney
- Nadir Yehya (ORCID: https://orcid.org/0000-0002-2996-217X)
- Brian Michael Varisco (ORCID: https://orcid.org/0000-0003-0180-2577)
- Scott L. Weiss (ORCID: https://orcid.org/0000-0002-7040-3281)
- Mihir R. Atreya (ORCID: https://orcid.org/0000-0002-8302-0984)
- James Garrett Williams (ORCID: https://orcid.org/0000-0002-3790-8413)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- Nemours Children's Health System (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- CHEST Critical Care
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.chstcc.2024.100120
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Cincinnati Children's Hospital Medical Center
- Cincinnati Children’s Research Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development