IL‐17A Mediates Depressive‐Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice
In the pathological condition of psoriasis, systemic IL-17A elevation can trigger microglia activation, provoke pro-inflammation mediators to release, evoke neuroinflammation, subsequently inhibit hippocampal neurogenesis, and result in depression. IL-17A, as an important pathogenic factor in psoriasis, contributes to its critical role in mediating systemic inflammation and depression comorbidity.
Authors
- Yawen Lin (ORCID: https://orcid.org/0000-0001-5324-6328)
- Lei Ma (ORCID: https://orcid.org/0000-0002-8390-3242)
- Xinxin Li (ORCID: https://orcid.org/0000-0002-2866-5691)
- Jingjing You
- Jing Wang (ORCID: https://orcid.org/0000-0001-9491-4994)
- Bin Liu (ORCID: https://orcid.org/0000-0002-9355-2239)
- Yue Dou
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/iid3.70092
- Citations
- 6
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province