Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936
The in-utero and early-life exposure to PM<sub>2.5</sub> and NO<sub>2</sub> was associated with higher AD and all-cause dementia risk, suggesting a sensitive/critical period. Cumulative exposure to PM<sub>2.5</sub> across the life course was associated with higher dementia risk. Midlife PM<sub>2.5</sub> exposure's negative association with all-cause dementia risk may stem from unaddressed confounders or bias.
Authors
- Sam Tomlinson (ORCID: https://orcid.org/0000-0002-3237-7596)
- Donncha S. Mullin (ORCID: https://orcid.org/0000-0002-1679-8067)
- Otto‐Emil Ilmari Jutila (ORCID: https://orcid.org/0000-0002-5681-958X)
- Tom C. Russ (ORCID: https://orcid.org/0000-0001-9797-2188)
- Ian J. Deary (ORCID: https://orcid.org/0000-0002-1733-263X)
- Jamie Pearce (ORCID: https://orcid.org/0000-0002-0994-7140)
- Michelle Luciano (ORCID: https://orcid.org/0000-0002-7306-3008)
- Simon R. Cox (ORCID: https://orcid.org/0000-0003-4036-3642)
- Gergő Baranyi (ORCID: https://orcid.org/0000-0002-3287-3629)
- Massimo Vieno (ORCID: https://orcid.org/0000-0001-7741-9377)
- Ida Karlsson (ORCID: https://orcid.org/0000-0003-3605-7829)
- Janie Corley (ORCID: https://orcid.org/0000-0002-7551-1871)
- Adele Taylor
Institutions
- NHS Lothian (GB)
- Karolinska Institutet (SE)
- Alzheimer Scotland (GB)
- UK Centre for Ecology & Hydrology (GB)
- University College London (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Environmental Epidemiology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1097/ee9.0000000000000355
- Citations
- 7
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Economic and Social Research Council