Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma
Our study adopted a multi-omics approach to unravel the impact of intratumoral microbes on neuron-related gene expression through bacteria-associated metabolites. Importantly, we found bacterial RNA and LPS signals within glioma tissues, which were traditionally considered sterile. We identified key microbiota within glioma tissues, including <i>Fusobacterium nucleatum</i> (Fn). Through <i>in vivo</i> and <i>in vitro</i> experiments, we identified the crucial role of Fn in promoting glioma progression, suggesting that Fn could be a potential diagnostic and therapeutic target for glioma patients. These findings offer valuable insights into the intricate interplay between intratumoral bacteria and glioma, offering novel inspiration to the realm of glioma biology.
Authors
- Yugu Xie
- Meiqin Zeng
- Cheng Wang (ORCID: https://orcid.org/0009-0002-6231-3523)
- Zhencheng Fang (ORCID: https://orcid.org/0000-0002-0137-4683)
- Hongwei Zhou (ORCID: https://orcid.org/0000-0002-9478-4023)
- Zhanyi Zhao
- Feiyang Luo
- Ting Li (ORCID: https://orcid.org/0000-0002-2335-4886)
- Jiaxuan Wang (ORCID: https://orcid.org/0000-0003-0902-591X)
- Haitao Sun
- Lu Zhang (ORCID: https://orcid.org/0000-0003-4669-8240)
- Yunhao Luo (ORCID: https://orcid.org/0000-0002-3936-2514)
- Kaijian Sun
- Jiandong Huang (ORCID: https://orcid.org/0000-0001-7531-2816)
- Meichang Peng
- Cui Lv
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Sciences (CN)
- Zhujiang Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- mSystems
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1128/msystems.00457-24
- Citations
- 20
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province