Prognostic value of tertiary lymphoid structures in triple-negative breast cancer: integrated analysis with the tumor microenvironment and clinicopathological features
Our results suggest that TLS are a frequent feature in early TNBC and that their presence, particularly at the tumor periphery, recapitulates the tumor immune microenvironment. In our series, their prognostic value outperformed that of TILs. Therefore, their easy quantification on routine HES sections and their integration into the factors classically analyzed by pathologists could improve the clinical management of TNBC, a breast cancer type whose prognosis remains too poor.
Authors
- Evelyne Lopez‐Crapez (ORCID: https://orcid.org/0000-0002-8261-3470)
- Pascal Roger (ORCID: https://orcid.org/0000-0002-4040-5892)
- Florence Boissière‐Michot (ORCID: https://orcid.org/0000-0003-2431-5157)
- Virginie Lafont (ORCID: https://orcid.org/0000-0001-9612-3934)
- Séverine Guiu (ORCID: https://orcid.org/0000-0002-4901-6295)
- Marie‐Christine Chateau
- William Jacot (ORCID: https://orcid.org/0000-0001-7834-061X)
- Priyanka Sharma (ORCID: https://orcid.org/0000-0001-9270-8492)
- Angélique Bobrie (ORCID: https://orcid.org/0000-0003-0127-7709)
- Simon Thézenas (ORCID: https://orcid.org/0000-0003-2472-1219)
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Zimmer Biomet (France) (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Université de Nîmes (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1507371
- Citations
- 13
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- Agence Nationale de la Recherche