Diagnosis value of targeted and metagenomic sequencing in respiratory tract infection
Collectively, tNGS presented a similar overall performance in pathogen identification compared to mNGS, but outperformed in some pathogens. This study also demonstrated that deployment of tNGS significantly improves etiology identification in routine practice and provides hints for clinical decisions. The low agreement between clinical diagnosis and NGS reports towards opportunistic pathogens implies that adjudication is essential for report interpretation. Finally, We proposed tNGS as a diagnosis option in clinical practice due to its cost-efficiency.
Authors
- Yukun Kuang (ORCID: https://orcid.org/0000-0002-3342-4489)
- Ke-Jing Tang
- Ji‐Yu Wang (ORCID: https://orcid.org/0000-0002-0681-4836)
- Xie Can-mao (ORCID: https://orcid.org/0000-0002-7709-3263)
- Lihong Bai
- Pengyuan Zhu (ORCID: https://orcid.org/0000-0002-1070-1535)
- Rong He (ORCID: https://orcid.org/0000-0001-5779-951X)
- Haihong Chen (ORCID: https://orcid.org/0000-0002-7584-0229)
- Zhaoxi Ke
- Huai Liao
- Chaohui Hu
- Jun Liu
- Weiping Tan
- Zehan Dai
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fcimb.2024.1498512
- Citations
- 9
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 3.48
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University