Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections
This study reveals the differences in the fate and release of modified nucleosides in bacteria and mammals. Additionally, our study highlights that external bacteria-damaging factors, such as antibiotics and phagocytosis by host immune cells, promote the release of bacteria-specific modified nucleosides. Furthermore, we found that m<sup>2</sup>A was elevated in the urine from animal models of bacterial infection and the urine of patients with bacterial infections. Collectively, this work spans basic biology and clinical science, offering valuable insights into the fate of modified nucleosides in bacterial systems and their relevance to infectious diseases.
Authors
- Hitomi Kaneko
- Yu Nagayoshi (ORCID: https://orcid.org/0000-0003-2971-5803)
- Koki Matsushita
- Akihiro Kunisawa
- Yutaka Kakizoe
- Yuichiro Izumi (ORCID: https://orcid.org/0000-0003-0827-9619)
- Ryosuke Yamamura (ORCID: https://orcid.org/0000-0002-0117-4091)
- Masashi Mukoyama (ORCID: https://orcid.org/0000-0001-5636-4039)
- Kazuhito Tomizawa (ORCID: https://orcid.org/0000-0002-5663-2627)
- Takashige Kuwabara (ORCID: https://orcid.org/0000-0003-3507-4328)
- Michio Shimamura (ORCID: https://orcid.org/0000-0002-3130-6470)
- Masataka Adachi (ORCID: https://orcid.org/0000-0001-5139-2532)
- Korin Sakakida
- Kayo Nishiguchi
- Takeshi Chujo (ORCID: https://orcid.org/0000-0003-2393-5776)
- Keiichi Yamamoto
Institutions
- Kumamoto University Hospital (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- mBio
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1128/mbio.03124-24
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science