Unbound Ceftriaxone Concentrations in Plasma Measured Using Ultrafiltration Versus Equilibrium Dialysis
Ultrafiltration substantially overestimates the unbound ceftriaxone fraction compared with equilibrium dialysis at 37°C. It is important to report methodological details and consider this information when interpreting unbound fractions of ceftriaxone and other drugs. These findings may impact the therapeutic drug monitoring of ceftriaxone.
Authors
- Matthias Gijsen (ORCID: https://orcid.org/0000-0003-1378-3772)
- Pieter Annaert (ORCID: https://orcid.org/0000-0003-3525-7351)
- Dorian Vanneste (ORCID: https://orcid.org/0000-0002-8871-7385)
- Yves Debaveye (ORCID: https://orcid.org/0000-0003-1784-8297)
- Joost Wauters (ORCID: https://orcid.org/0000-0002-5983-3897)
- Isabel Spriet (ORCID: https://orcid.org/0000-0001-6342-0676)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- Pharmac (NZ)
- KU Leuven (BE)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1097/ftd.0000000000001294
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00