Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023–2024
We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro.
Authors
- Jakob Ankerhold (ORCID: https://orcid.org/0000-0002-1524-9445)
- Martin Schwemmle (ORCID: https://orcid.org/0000-0002-2972-6855)
- Susanne Kessler (ORCID: https://orcid.org/0000-0002-9720-8291)
- Martin Beer (ORCID: https://orcid.org/0000-0002-0598-5254)
- Kevin Ciminski (ORCID: https://orcid.org/0000-0001-5397-7497)
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3201/eid3101.241236
- Citations
- 3
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16