Genotype and Associated Cancer Risk in Individuals With Telomere Biology Disorders
This cohort study of individuals with TBDs found an increased cancer risk compared with the general population, with the earliest age at onset for individuals with AR/XLR inheritance. Cancer risks increased after organ transplant across all subgroups. These differences in TBD-associated cancer risks by mode of inheritance suggest cancer screening could be tailored by genotype, but additional research is warranted.
Authors
- Sharon A. Savage (ORCID: https://orcid.org/0000-0001-6006-0740)
- Marena R. Niewisch (ORCID: https://orcid.org/0000-0002-9565-5565)
- Lisa J. McReynolds
- Judith C. Lunger (ORCID: https://orcid.org/0000-0002-6241-1070)
- Neelam Giri (ORCID: https://orcid.org/0000-0001-7353-1863)
- Jung Kim (ORCID: https://orcid.org/0000-0001-6274-2841)
Institutions
- National Institutes of Health (US)
- Medizinische Hochschule Hannover (DE)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.50111
- Citations
- 10
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Deutsche Krebshilfe
- National Cancer Institute
- Division of Cancer Epidemiology and Genetics, National Cancer Institute