Itaconate Ameliorates Experimental Autoimmune Uveitis by Modulating Teff/Treg Cell Imbalance Via the DNAJA1/CDC45 Axis
Our research delved into the potential therapeutic mechanisms underlying ITA therapy in EAU, offering fresh perspectives on its utility in the treatment of autoimmune conditions. DNAJA1 emerges as a promising candidate for targeted therapeutic interventions in uveitis.
Authors
- Wenru Su (ORCID: https://orcid.org/0000-0002-0506-6362)
- Yao Huang (ORCID: https://orcid.org/0000-0002-9990-5138)
- Xiuxing Liu (ORCID: https://orcid.org/0000-0001-5855-6624)
- Tianfu Wang (ORCID: https://orcid.org/0000-0002-1248-1214)
- Chenyang Gu (ORCID: https://orcid.org/0009-0008-6022-3341)
- Zhaohuai Li
- Qi Jiang (ORCID: https://orcid.org/0000-0002-2187-5856)
- He Li (ORCID: https://orcid.org/0000-0001-7891-9998)
- Junjie Chen (ORCID: https://orcid.org/0000-0002-8984-1986)
- Chun Zhang (ORCID: https://orcid.org/0000-0003-3565-8024)
- Yingqi Li (ORCID: https://orcid.org/0000-0002-4423-7830)
- Zhaohao Huang (ORCID: https://orcid.org/0000-0002-6958-2673)
Institutions
- Guiyang Medical University (CN)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Shanghai Ninth People's Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1167/iovs.65.14.23
- Citations
- 3
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China