EVALUATION OF THE EFFECT OF THE MUCOPROTECTIVE SPRAY ON PERIODONTAL INFLAMMATION: RHEOLOGICAL PARAMETERS OF MIXED SALIVA

Subject. The subject of the study is a mucoprotective spray, mixed saliva. Objectives. The aim of the study was to evaluate the effectiveness of use of the mucorotective spray on periodontal inflammation by analyzing dynamic changes in the rheological properties of mixed saliva. Methodology. The study is conducted by the Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases, the Department of General Chemistry, Ural State Medical University. The research objects are: 1 – the spray with mucoprotector, titanium glycerosolvate aquacomplex used as an “inorganic nanoparticle” with high delivery capabilites into deep tissue layers and activity enhancement of anti–inflammatory, antimicrobial and regenerating components of the spray; 2 – the spray without titanium glycerosolvate aquacomple (aqueous solution), placebo. The study involved 30 dental volunteer students whose average age was 20.5 ± 0.95 years (12 young men, 18 young women) with periodontal inflammation. Two groups were formed consisting of 15 people each who used the study sprays during two weeks. The dynamic changes in the rheological parameters of mixed saliva were determined by the following methods: measuring salivary flow rates, viscosity measurements, evaluation of surface tension of mixed saliva to characterize its rinsing function and cleansing properties. Conclusions. Analysis of the findings shows high effectiveness of use of the mucorotective spray on the basis of titanium glycerosolvate aquacomplex with anti-inflammatory effect, that is confirmed by the dynamic changes in the hygiene index and the PMA index (p ⩽ 0.05). The spray has got high trans-mucus penetration and good tolerability; it is easy to use and economically affordable. The analysis of changes in the rheological parameters of mixed saliva in patients from the first group during the application course of the spray on the basis of the the titanium glycerosolvate aquacomplex mucoprotector showed increased saliva flow rates and decreased viscosity of saliva. These enhance the rheological propertiies of mixed saliva, its rinsing function and cleansing properties, as well reduce the risk of tooth decay and gum swelling, and prevent dental deposits in patients with periodontal inflammation.