Multimodal Longitudinal Optical Imaging Reveals Optic Neuritis Preceding Retinal Pathology in Experimental Autoimmune Encephalomyelitis
Our work identifies the recruitment of CX3CR1+ cells to the ON as an early sign of disease underlining the importance of combined structural and functional retinal imaging for the spatiotemporal characterization of neuroinflammatory and neurodegenerative processes. It further proposes retinal phagocyte orientation, morphology, and abundance as potential surrogate markers for neurodegenerative activity.
Authors
- Raphael Raspe (ORCID: https://orcid.org/0000-0003-3409-4968)
- Helena Radbruch (ORCID: https://orcid.org/0000-0001-6941-3397)
- Robert Günther (ORCID: https://orcid.org/0000-0002-3533-9747)
- Ralf Uecker
- Asylkhan Rakhymzhan (ORCID: https://orcid.org/0000-0003-3152-1557)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Anja E. Hauser (ORCID: https://orcid.org/0000-0002-7725-9526)
- Raluca Niesner (ORCID: https://orcid.org/0000-0001-8969-5432)
Institutions
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1212/nxi.0000000000200338
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- Deutsche Forschungsgemeinschaft
- Berlin Institute of Health