Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine
S. boulardii CNCM I-745 possesses relaxant properties on the rat ileum involving the inhibition of 5-HT and more specifically 5-HT<sub>1A</sub> and 5-HT<sub>2A/2B/2C</sub> receptor-induced contractions. These data suggest that the attenuation of 5-HT-induced ileal contractions by S. boulardii represents a probable mechanism of action sustaining its efficacy in patients affected by IBS with diarrhea.
Authors
- Vincent Castagné (ORCID: https://orcid.org/0000-0002-8728-2922)
- Marc Verleye
- Philippe Girard
Institutions
- Biocodex (France) (FR)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1007/s10620-024-08786-y
- Citations
- 2
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.93