HLA B*15:02 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: first case report from Nepal with genetic analysis
This case underscores the necessity of recognizing carbamazepine-induced SJS/TEN risk, particularly in HLA-B*1502 carriers. Despite screening challenges, early intervention involving multidisciplinary specialists is essential for favorable outcomes. Increased awareness and proactive measures are vital in preventing and managing these severe reactions.
Authors
- Subash Sapkota (ORCID: https://orcid.org/0000-0001-8588-5626)
- Bimarsh Acharya (ORCID: https://orcid.org/0000-0003-4123-1668)
- Manoj Joshi (ORCID: https://orcid.org/0000-0003-4551-8279)
- Sachin A. Shah (ORCID: https://orcid.org/0000-0001-5850-1113)
- Karuna Khati
- Dissanayake M. L. Randuwini Dissanayake
- Jayanti Jawarchan
Institutions
- Manipal College of Medical Sciences (NP)
- KIST Medical College (NP)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1097/ms9.0000000000002736
- Citations
- 1
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.45