Bifunctional Sodium Dithionite Promoted Radical-Polar Crossover Cyclization: Diversified Synthesis of Functionalized Cyclic Sultines
A catalyst-free reductive radical-polar crossover cyclization with alkenes and sodium dithionite to construct densely functionalized cyclic sultines was described. The key to the success of this practical protocol relies not only on a bifunctional role of sodium dithionite, that is, serving as radical initiator and SO<sub>2</sub> source, but also on the diversified conversions (RPCC/SO<sub>2</sub> insertion/S<sub>N</sub>2 cyclization and RPCC/SO<sub>2</sub> insertion/1,4-addition cyclization processes), which enabled efficient construction of target compounds with the high efficiency and atom- and step-economy under mild conditions.
Authors
- Zhonglin Wei (ORCID: https://orcid.org/0000-0002-9032-0889)
- Cheng-Jing Li
- Wei‐Wei Liao (ORCID: https://orcid.org/0000-0001-6225-4258)
- Mengyu Liu (ORCID: https://orcid.org/0009-0002-5493-7897)
Institutions
- Jilin University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1021/acs.joc.4c02606
- Citations
- 3
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- State Key Laboratory of Supramolecular Structure and Materials
- National Key Research and Development Program of China