Does fragmented sleep mediate the relationship between deficits in sleep spindles and memory consolidation in schizophrenia?
Our findings fail to support the hypothesis that sleep fragmentation accounts for spindle deficits, impaired SDMC, or their relationship in individuals with chronic schizophrenia. Instead, our findings are consistent with the hypothesis that spindle deficits directly impair memory consolidation in schizophrenia. Since sleep continuity and architecture are intact in this population, research aimed at developing interventions should instead focus on understanding dysfunction within the thalamocortical-hippocampal circuitry that both generates spindles and synchronizes them with other NREM oscillations to mediate SDMC.
Authors
- Dimitrios Mylonas (ORCID: https://orcid.org/0000-0003-0924-7731)
- Olivia Larson (ORCID: https://orcid.org/0000-0003-3887-7476)
- Bryan Baxter (ORCID: https://orcid.org/0000-0003-3056-0204)
- Márk Vangel (ORCID: https://orcid.org/0000-0003-2993-2365)
- Lin Zhu (ORCID: https://orcid.org/0000-0003-0473-280X)
- Dara S. Manoach (ORCID: https://orcid.org/0000-0001-9208-1167)
- Rudra Patel (ORCID: https://orcid.org/0009-0007-3932-6429)
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- SLEEP Advances
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1093/sleepadvances/zpae090
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- Harvard Catalyst
- National Institutes of Health
- National Center for Research Resources