Impact of radiation therapy dose, fractionation, and immunotherapeutic partner in a mouse model of hormone receptor–positive mammary carcinogenesis
In this model of HR+ mammary carcinogenesis, RT to the primary tumor ameliorates overall survival (to an extent based on dose and fractionation). Increasing local control through RT alone or RT plus immunotherapy beyond a hitherto undefined threshold, however, does not necessarily inhibit the development of subsequent nonirradiated neoplasms and hence does not necessarily provide extra overall survival benefits.
Authors
- Aitziber Buqué
- Manuel Beltrán‐Visiedo (ORCID: https://orcid.org/0000-0002-7977-8020)
- Silvia C. Formenti (ORCID: https://orcid.org/0000-0002-8227-8924)
- Tania Pannellini
- Andrea Guarracino (ORCID: https://orcid.org/0000-0001-9744-131X)
- Bhavneet Bhinder (ORCID: https://orcid.org/0000-0001-6685-8761)
- Xi Kathy Zhou (ORCID: https://orcid.org/0000-0002-8942-439X)
- Giulia Petroni (ORCID: https://orcid.org/0000-0002-0558-5322)
- Brady Rippon
- Carlos Jiménez‐Cortegana (ORCID: https://orcid.org/0000-0001-6956-7740)
- Jitka Fučíková (ORCID: https://orcid.org/0000-0002-8423-479X)
- Sandra Demaria (ORCID: https://orcid.org/0000-0003-4426-0499)
- Cristina Iribarren (ORCID: https://orcid.org/0000-0002-0632-7552)
- Ruth Soler-Agesta (ORCID: https://orcid.org/0000-0003-3153-389X)
- Olivier Elemento (ORCID: https://orcid.org/0000-0002-8061-9617)
- Claudia Galassi (ORCID: https://orcid.org/0000-0003-1502-4390)
- Lorenzo Galluzzi (ORCID: https://orcid.org/0000-0003-2257-8500)
- Norma Bloy (ORCID: https://orcid.org/0000-0001-5758-9424)
- Michal Hensler (ORCID: https://orcid.org/0000-0002-8767-0722)
- Takahiro Yamazaki
- Ai Sato
Institutions
- Fox Chase Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Cornell University (US)
- Charles University (CZ)
- Universidad de Zaragoza (ES)
- Lander Institute (IL)
- University Hospital in Motol (CZ)
- CancerCare (US)
- Sotio (Czechia) (CZ)
- Human Technopole (IT)
- Weill Cornell Medicine (US)
- University of Florence (IT)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/jnci/djae329
- Citations
- 9
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- U.S. Department of Defense
- Leukemia and Lymphoma Society
- National Institutes of Health
- Weill Cornell Medical College
- Stand Up To Cancer
- National Cancer Institute