<i>Plasmodium falciparum</i> African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost
These findings suggest that piperaquine-resistant PfCRT mutations that emerged in Southeast Asia mediate resistance only in a limited subset of African PfCRT haplotypes, with fitness costs that we suspect would likely preclude dissemination in high-transmission malaria-endemic African regions.
Authors
- Laura M. Hagenah (ORCID: https://orcid.org/0000-0001-8258-6823)
- Kyra A. Schindler (ORCID: https://orcid.org/0000-0002-4406-9160)
- Jennifer L. Small-Saunders (ORCID: https://orcid.org/0000-0001-6064-2249)
- Tomas Yeo (ORCID: https://orcid.org/0000-0003-2923-6060)
- Sachel Mok (ORCID: https://orcid.org/0000-0002-9605-0154)
- Jin Yong Jeon (ORCID: https://orcid.org/0000-0002-1469-4520)
- David A. Fidock (ORCID: https://orcid.org/0000-0001-6753-8938)
- Talia S. Bloxham (ORCID: https://orcid.org/0009-0002-8613-0457)
Institutions
- Columbia University Irving Medical Center (US)
- CNR de la Résistance aux Antibiotiques (FR)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1093/infdis/jiae617
- Citations
- 5
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 2.71