Numerical Algorithm of Effective Cancer Treatment Based on the Fisher-Kolmogorov Equation

An inverse extremal problem for the Fisher-Kolmogorov model of tumor growth is studied. It is required to minimize the normalized density of tumor cells in a given subdomain, while the drug concentration in the tissue must be limited to specified values. The solvability of the inverse extremal problem is established. An algorithm to find its solution is constructed. The numerical experiments illustrate its efficiency.

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Publication Details

Journal
EPiC series in computing
Published
2024-12-11
DOI
https://doi.org/10.29007/z3mk
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
0.00

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article

Numerical Algorithm of Effective Cancer Treatment Based on the Fisher-Kolmogorov Equation

Andrey Kovtanyuk, Christina Kuttler, A. Yu. Chebotarëv
EPiC series in computing
Mathematical Biology Tumor Growth
article

Numerical Algorithm of Effective Cancer Treatment Based on the Fisher-Kolmogorov Equation

Andrey Kovtanyuk, Christina Kuttler, A. Yu. Chebotarëv
article en

Abstract

An inverse extremal problem for the Fisher-Kolmogorov model of tumor growth is studied. It is required to minimize the normalized density of tumor cells in a given subdomain, while the drug concentration in the tissue must be limited to specified values. The solvability of the inverse extremal problem is established. An algorithm to find its solution is constructed. The numerical experiments illustrate its efficiency.

EPiC series in computingVol. 104
Ministry of Science and Higher Education of the Russian Federation
Good health and well-being
Openalex Percentile: Top 76%
Mathematical Biology Tumor Growth
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Numerical Algorithm of Effective Cancer Treatment Based on the Fisher-Kolmogorov Equation — Andrey Kovtanyuk, Christina Kuttler, et al. · EPiC series in computing (2024) | TGRS Research Map | TGRS