Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy
The current study identifies upregulation of specific PDE4D isoforms that selectively inhibit SERCA2a function in HFD-induced cardiomyopathy, indicating that this remodelling can be targeted to restore cardiac contractility in diabetic cardiomyopathy.
Authors
- Yongsheng Han
- Toni M. West (ORCID: https://orcid.org/0000-0001-7665-1860)
- Zhenduo Zhu (ORCID: https://orcid.org/0000-0002-7711-7632)
- Qiuyun Guan (ORCID: https://orcid.org/0000-0003-1043-5799)
- Ao Shen (ORCID: https://orcid.org/0000-0002-1559-3895)
- Sherif Bahriz (ORCID: https://orcid.org/0000-0002-9310-8349)
- Qingtong Wang
- Yang K. Xiang (ORCID: https://orcid.org/0000-0003-1786-9143)
- Bing Xu (ORCID: https://orcid.org/0009-0007-2766-8755)
- Wei Wei (ORCID: https://orcid.org/0000-0002-3117-9598)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-8121-3678)
- Bingqing Deng (ORCID: https://orcid.org/0000-0003-3736-6041)
Institutions
- University of Science and Technology of China (CN)
- Ministry of Education of the People's Republic of China (CN)
- Sun Yat-sen University (CN)
- Anhui Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- VA Northern California Health Care System (US)
- University of California, Davis (US)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1111/bph.17411
- Citations
- 3
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- American Heart Association
- National Natural Science Foundation of China
- Anhui Medical University