Retinal fluid quantification using a novel deep learning algorithm in patients treated with faricimab in the TRUCKEE study
Deep-learning algorithms provide a novel tool for evaluating precise quantification of retinal fluid after treatment of nAMD with faricimab. Faricimab demonstrates reduction of retinal fluid in multiple groups after just one injection and sustains this response after multiple treatments, along with providing increases in treatment intervals between subsequent injections.
Authors
- Huma Khan
- Veeral Sheth (ORCID: https://orcid.org/0000-0002-7467-9947)
- Emily Lauer (ORCID: https://orcid.org/0000-0001-7035-1509)
- Aamir Aziz (ORCID: https://orcid.org/0000-0002-3657-4861)
- Srinivas R. Sadda (ORCID: https://orcid.org/0000-0002-4939-3306)
- Mark Barakat (ORCID: https://orcid.org/0000-0002-1328-6314)
- Giulia Corradetti (ORCID: https://orcid.org/0000-0001-9213-5575)
- Arshad M. Khanani (ORCID: https://orcid.org/0000-0001-8928-5599)
- Hannah Khan
- Jared S. Nielsen (ORCID: https://orcid.org/0000-0003-4321-1978)
- Ibrahim Khanani
- Gidi Benyamini (ORCID: https://orcid.org/0000-0003-4496-8462)
- Irit Hadas
- Ashkan M. Abbey (ORCID: https://orcid.org/0000-0002-8719-6709)
- Greggory M Gahn (ORCID: https://orcid.org/0000-0003-2393-8002)
- Sara J. Haug
- Kester Nahen (ORCID: https://orcid.org/0009-0000-3271-8250)
- Ohidul Mojumder
- Zoha A. Khanani
- David R.P. Almeida (ORCID: https://orcid.org/0000-0002-1742-1683)
- Jordan M. Graff
- J. Taylor Graff
- Nishant Mohan
Institutions
- Midwestern University (US)
- University of Nevada, Reno (US)
- Duke University (US)
- Macula and Retina Institute (US)
- Retina Macula Institute (US)
- Doheny Eye Institute (US)
- Minnesota Eye Consultants (US)
- Notal Vision (Israel) (IL)
- Wolfe Eye Clinic (US)
- Illinois Retina Associates (US)
- Sierra Eye Associates (US)
- Texas Retina Associates (United States) (US)
Publication Details
- Journal
- Eye
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1038/s41433-024-03532-0
- Citations
- 8
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- Amgen
- Biogen
- Alexion Pharmaceuticals
- Regeneron Pharmaceuticals
- BioCryst
- Alimera Sciences
- Celltrion
- NGM Biopharmaceuticals
- Apellis Pharmaceuticals
- Coherus Biosciences
- Astellas Pharma
- Genentech