Reversing resistance to cancer immune therapy with antibodies that target GDF-15 protein

The protein GDF-15 is a potent immunosuppressor that is overexpressed in many solid tumours and impedes the effects of cancer immunotherapy. In a first-in-human clinical trial, the GDF-15-targeting antibody visugromab reversed GDF-15-mediated resistance to immunotherapy, resulting in deep, long-lasting tumour regressions in some individuals. Resistance to conventional immunotherapy can be broken by a combination of agents.

Publication Details

Journal
Nature
Published
2024-12-11
DOI
https://doi.org/10.1038/d41586-024-04081-y
Primary Topic
GDF15 and Related Biomarkers
Type
article
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Reversing resistance to cancer immune therapy with antibodies that target GDF-15 protein

Nature
GDF15 and Related Biomarkers
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Reversing resistance to cancer immune therapy with antibodies that target GDF-15 protein

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Abstract

The protein GDF-15 is a potent immunosuppressor that is overexpressed in many solid tumours and impedes the effects of cancer immunotherapy. In a first-in-human clinical trial, the GDF-15-targeting antibody visugromab reversed GDF-15-mediated resistance to immunotherapy, resulting in deep, long-lasting tumour regressions in some individuals. Resistance to conventional immunotherapy can be broken by a combination of agents.

Nature
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GDF15 and Related Biomarkers
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Reversing resistance to cancer immune therapy with antibodies that target GDF-15 protein · Nature (2024) | TGRS Research Map | TGRS