Fibroblast activation protein inhibitors positron emission tomography/computed tomography: Review of the literature

Positron emission tomography/computed tomography (PET/CT) with radiolabeled fibroblast activation protein inhibitors (FAPI) is an increasingly relevant molecular diagnostic image in oncology given the high expression of FAP in cancer associated fibroblast, being present in almost 90% of the epithelial carcinomas, which allows imaging with excellent diagnostic performance and can also become a therapeutic strategy. This review summarizes the literature on FAPI-PET/CT for the cancer evaluation and compares it in some scenarios with the 18F-Fluorodeoxyglucose PET/CT.