JAK/STAT Pathway as a Double-Edged Sword in Myocardial Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion injury (MIRI) is a serious injury to ischemic myocardium after blood flow recovery, and it is the focus and difficulty of cardiovascular disease treatment.The JAK/STAT signaling pathway is a double-edged sword in MIRI.The activation of STAT1 can promote cardiomyocyte apoptosis and aggravate myocardial injury.STAT3 can reduce myocardial injury by up regulating anti apoptotic protein, but inhibiting the activation of the JAK2/STAT3 signaling pathway under oxidative stress can protect myocardium.