ERLNs augment simultaneous delivery of GFSV into PC-3 cells: Influence of drug combination on SDH, GPX-4, 5α-RD, and cytotoxicity
This study concludes that SVGF combination and ERLNs loading induce particular delivery, and synergism on PC-3 death through action on multiple pathways involved in cell proliferation, and apoptosis, besides the interaction with SDH, GPX-4, and 5α-RD. Therefore, GFSV-loaded ERLN cargoes are a promising strategy for PCA treatment. <i>In vivo</i> studies are necessary to confirm these findings for clinical applications.
Authors
- Gamaleldin I. Harisa (ORCID: https://orcid.org/0000-0002-7988-4421)
- Sabry Mohamed Attia (ORCID: https://orcid.org/0000-0001-8560-8944)
- Riyad F. Alzhrani (ORCID: https://orcid.org/0000-0003-2677-0401)
- Ahmed H.H. Bakheit (ORCID: https://orcid.org/0000-0002-0445-1357)
- Hanadi H. Asiri (ORCID: https://orcid.org/0009-0005-1649-7749)
- Ali Alhoshani (ORCID: https://orcid.org/0000-0002-3450-283X)
- Lama Binobaid (ORCID: https://orcid.org/0000-0001-6914-8853)
- Meshal Alsahli
- Abdulaziz A Aloraini
Institutions
- King Saud University (SA)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2024-12-11
- DOI
- https://doi.org/10.32604/or.2024.054537
- Citations
- 2
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.10