Microglia and brain macrophages are differentially associated with tumor necrosis in glioblastoma: A link to tumor progression
Resident microglia seem more likely to be important for the diffuse infiltration of glioma cells in hypercellular tissue areas, whereas myeloid macrophages may be the main macrophage population in the wake of tumor necrosis. Since the necrotic niche with its interactions between microglia, brain macrophages, and glioblastoma/glioma stem cells is increasingly recognised as an important factor in tumor progression, further detailed studies of the macrophage populations in glioblastoma are warranted.
Authors
- Anna K. Nowak (ORCID: https://orcid.org/0000-0002-9317-9526)
- Richard B. Banati (ORCID: https://orcid.org/0000-0003-3558-597X)
- Yang Song (ORCID: https://orcid.org/0000-0001-7716-9216)
- Weimin Cai (ORCID: https://orcid.org/0000-0002-0342-4912)
- Christina Loh
- Kerrie L. McDonald (ORCID: https://orcid.org/0000-0001-7471-2674)
- Kimberley L. Alexander (ORCID: https://orcid.org/0000-0002-7239-039X)
- Islam Alzoubi (ORCID: https://orcid.org/0000-0002-1711-7745)
- Myeongho Lee (ORCID: https://orcid.org/0009-0006-7229-3967)
- Yuqi Zheng (ORCID: https://orcid.org/0000-0003-3859-3609)
- Manuel B. Graeber
Institutions
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Cancer Australia (AU)
- Chris O’Brien Lifehouse (AU)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2024-12-11
- DOI
- https://doi.org/10.32604/or.2024.056436
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99