Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study
The findings of this study confirm that AKI is a significant independent predictor of MACE in CKD patients, demonstrating a strong severity-response relationship. These results underscore the importance of vigilant cardiovascular monitoring and preventive strategies in CKD patients following AKI episodes. Understanding the mechanisms linking AKI to cardiovascular outcomes is crucial for developing targeted interventions to mitigate these risks.
Authors
- Victoria Gauthier (ORCID: https://orcid.org/0000-0001-9997-235X)
- Thomas Beaudrey (ORCID: https://orcid.org/0009-0000-2983-2773)
- Estelle Aymes (ORCID: https://orcid.org/0000-0002-3652-7440)
- Sophie Liabeuf (ORCID: https://orcid.org/0000-0001-5384-9006)
- Philippe Amouyel (ORCID: https://orcid.org/0000-0001-9088-234X)
- Nans Florens (ORCID: https://orcid.org/0000-0002-0960-6055)
- Bénédicte Stengel (ORCID: https://orcid.org/0000-0001-9469-0804)
- Ziad A. Massy (ORCID: https://orcid.org/0000-0001-5771-5996)
- Nicolas Mansencal (ORCID: https://orcid.org/0000-0001-5500-1535)
- Luc Frimat (ORCID: https://orcid.org/0000-0002-8611-7351)
- Aghilès Hamroun (ORCID: https://orcid.org/0000-0003-4988-206X)
- Natália Alencar de Pinho (ORCID: https://orcid.org/0000-0002-0438-6487)
- Maurice Laville
- Céline Lange
- Dimitri Bedo
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Institut Pasteur de Lille (FR)
- Public Health Department (IN)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (FR)
- Agence de la Biomédecine (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Hôpital Civil, Strasbourg (FR)
- Association pour l'Utilisation du Rein Artificiel (FR)
- French Clinical Research Infrastructure Network (FR)
- Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est (FR)
- Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires (FR)
- Université de Picardie Jules Verne (FR)
- Université de Strasbourg (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1093/ckj/sfae337
- Citations
- 6
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.04
Funders
- Amgen
- Eli Lilly and Company
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- MSD France
- Fresenius Medical Care North America
- Agence Nationale de la Recherche
- Otsuka Pharmaceutical
- Sanofi Genzyme