Prognostic value of radiologic and pathological response in colorectal cancer liver metastases upon systemic induction treatment: subgroup analysis of the CAIRO5 trial
Our results show that RECIST but not morphologic response was prognostic for OS. In patients eligible for local treatment, neither RECIST nor morphologic response were associated with early recurrence. Pathological response was associated with early recurrence but is only available post-operatively. Hence, novel preoperative parameters are warranted to predict early recurrence and prevent potentially futile liver surgery.
Authors
- Clinton Mijnals (ORCID: https://orcid.org/0000-0002-1080-8877)
- Marinde J. G. Bond (ORCID: https://orcid.org/0000-0003-0225-5456)
- John J. Hermans (ORCID: https://orcid.org/0000-0001-9207-0548)
- Rutger‐Jan Swijnenburg (ORCID: https://orcid.org/0000-0002-3980-4634)
- Cornelis J.A. Punt (ORCID: https://orcid.org/0000-0003-0846-1445)
- Anne M. May (ORCID: https://orcid.org/0000-0001-7551-9200)
- Krijn P. van Lienden (ORCID: https://orcid.org/0000-0001-7102-2213)
- Karen Bolhuis (ORCID: https://orcid.org/0000-0001-5196-1790)
- Marc Engelbrecht
- M.J. van Amerongen
Institutions
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Sint Maartenskliniek (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.esmoop.2024.104075
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Roche