UHPLC-MS/MS standardized extract of <i>Vernonia amygdalina</i> leaf inhibits CYP2C9 and CYP3A4 activities in hepatic cells of control and streptozotocin-induced diabetic rats
The UHPLC-MS/MS-MRM method is sensitive and reliable for the quality control of <i>V. amygdalina</i> leaf extract. The inhibitory effect of the extract suggests that concomitant use of <i>V. amygdalina</i> leaf preparations with conventional drugs metabolized and eliminated from the body by CYP3A4 and CYP2C9 enzymes may lead to possible interaction.
Authors
- Bassel Al. Sabbagh (ORCID: https://orcid.org/0000-0001-6431-8948)
- Jin Han Chin (ORCID: https://orcid.org/0000-0002-0042-4394)
- Yik-Ling Chew (ORCID: https://orcid.org/0000-0002-6733-5759)
- Gabriel Akyirem Akowuah (ORCID: https://orcid.org/0000-0001-5415-5516)
- Mariam Ahmad
- Palanirajan Vijayaraj Kumar (ORCID: https://orcid.org/0000-0003-1129-7084)
Institutions
- Monash University Malaysia (MY)
- Universiti Sains Malaysia (MY)
- Mahsa University (MY)
- UCSI University (MY)
Publication Details
- Journal
- Drug Metabolism and Personalized Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1515/dmpt-2024-0005
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00