Cytokine screening identifies TNF to potentially enhance immunogenicity of pediatric sarcomas
Our study supports utilization of TNF or TNF-inducing regimens for upregulation of MHC-I and costimulatory surface molecules on pediatric sarcoma cells and for enhancing recognition of responsive HLA-A2<sup>+</sup> EwS tumor cells by antigen-specific CD8<sup>+</sup> T cells.
Authors
- Leopold Flohé (ORCID: https://orcid.org/0000-0003-0940-8179)
- Kristina von Heyking
- Franziska Auer (ORCID: https://orcid.org/0000-0002-1193-6002)
- Uwe Thiel (ORCID: https://orcid.org/0000-0002-3574-7337)
- Carolin Prexler (ORCID: https://orcid.org/0000-0001-7136-0554)
- Melanie Thiede (ORCID: https://orcid.org/0000-0002-8291-8143)
- Mina N.F. Morcos (ORCID: https://orcid.org/0000-0001-5812-9526)
- Laszlo Radvanyi (ORCID: https://orcid.org/0000-0003-1603-3547)
- Julia Hauer (ORCID: https://orcid.org/0000-0002-4058-3058)
- Sebastian Johannes Schober (ORCID: https://orcid.org/0000-0002-5650-4035)
- Emilie Biele
- Israh Akhtar (ORCID: https://orcid.org/0000-0002-7189-0181)
- Hendrik Gassmann (ORCID: https://orcid.org/0000-0003-2503-4912)
- Valentina Evdokimova
- Helena Lachermaier
Institutions
- Ontario Institute for Cancer Research (CA)
- München Klinik Schwabing (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1347404
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Wilhelm Sander-Stiftung
- Deutsche Forschungsgemeinschaft
- Technische Universität München
- Deutschen Konsortium für Translationale Krebsforschung