Potential candidates from a functional food Zanthoxyli Pericarpium (Sichuan pepper) for the management of hyperuricemia: high-through virtual screening, network pharmacology and dynamics simulations
Our study provides foundations for exploring the mechanism of the lowering of uric acid by ZP and developing new products of ZP. The role of ZP in the diet may provide a new dietary strategy for the prevention of HUA, and more experimental studies are needed to confirm our results in the future.
Authors
- Xiaoshan Zhao (ORCID: https://orcid.org/0000-0003-3081-0103)
- Angela Wei Hong Yang (ORCID: https://orcid.org/0000-0001-9345-4607)
- Chenyang Chu
- Yanting You (ORCID: https://orcid.org/0000-0001-9511-9538)
- Andrew Hung (ORCID: https://orcid.org/0000-0003-3569-2951)
- Qinghong Chen
- Hong Li (ORCID: https://orcid.org/0000-0002-3874-4860)
- Yanyan Liu (ORCID: https://orcid.org/0000-0001-8959-9168)
- Meiling Chen (ORCID: https://orcid.org/0000-0002-1589-1710)
- Shuxuan Yang (ORCID: https://orcid.org/0000-0003-3237-1984)
- Xiaomin Sun (ORCID: https://orcid.org/0000-0001-9307-4735)
- Lin Zhou (ORCID: https://orcid.org/0000-0001-6457-9849)
- Chuanghai Wu
- Xiaomei Chen (ORCID: https://orcid.org/0000-0001-9822-7067)
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- RMIT University (AU)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fendo.2024.1436360
- Citations
- 6
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.04
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province
- National Supercomputing Center, Korea Institute of Science and Technology Information