Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study
Our study supports an independent role of genetic liability and polyenvironmental risk for psychosis, consistent with the liability threshold model. Whereas schizophrenia-spectrum disorders seem to be mostly associated with polygenic risk for schizophrenia, having an additive effect with well-replicated environmental factors, affective psychosis seems to be a product of cumulative environmental insults alongside a higher genetic liability for affective disorders.
Authors
- Celso Arango (ORCID: https://orcid.org/0000-0003-3382-4754)
- Stéphane Jamain (ORCID: https://orcid.org/0000-0002-4321-4100)
- Ilaria Tarricone (ORCID: https://orcid.org/0000-0002-5786-2520)
- Daniele La Barbera
- Pak C. Sham (ORCID: https://orcid.org/0000-0002-2533-7270)
- Luis Alameda (ORCID: https://orcid.org/0000-0002-8621-2885)
- Simona A. Stilo
- Diego Quattrone (ORCID: https://orcid.org/0000-0002-6051-8309)
- Jim van Os (ORCID: https://orcid.org/0000-0002-7245-1586)
- Miquel Bernardo (ORCID: https://orcid.org/0000-0001-8748-6717)
- Giada Tripoli (ORCID: https://orcid.org/0000-0002-9257-6677)
- Robin M. Murray (ORCID: https://orcid.org/0000-0003-0829-0519)
- Bart P. F. Rutten (ORCID: https://orcid.org/0000-0002-9834-6346)
- James B. Kirkbride (ORCID: https://orcid.org/0000-0003-3401-0824)
- Craig Morgan (ORCID: https://orcid.org/0000-0002-1386-2369)
- Manuel Arrojo (ORCID: https://orcid.org/0000-0002-5609-7134)
- Michael O’Donovan (ORCID: https://orcid.org/0000-0001-7073-2379)
- Caterina La Cascia (ORCID: https://orcid.org/0000-0002-2078-0214)
- Eva Velthorst (ORCID: https://orcid.org/0000-0002-9240-2909)
- Elena Bonora (ORCID: https://orcid.org/0000-0001-6132-7734)
- Charlotte Gayer‐Anderson (ORCID: https://orcid.org/0000-0003-1636-889X)
- Peter Brian Jones (ORCID: https://orcid.org/0000-0002-0387-880X)
- Victoria Rodríguez (ORCID: https://orcid.org/0000-0003-0383-0846)
- Evangelos Vassos (ORCID: https://orcid.org/0000-0001-6363-0438)
- Monica Aas (ORCID: https://orcid.org/0000-0002-2338-5826)
- Giulia Trotta (ORCID: https://orcid.org/0000-0003-2801-9718)
- Edoardo Spinazzola (ORCID: https://orcid.org/0000-0002-8070-0618)
- Antonio Lasalvia (ORCID: https://orcid.org/0000-0001-9963-6081)
- Hannah E. Jongsma (ORCID: https://orcid.org/0000-0001-6346-5903)
- Sarah Tosato (ORCID: https://orcid.org/0000-0002-9665-7538)
- Laura Ferraro (ORCID: https://orcid.org/0000-0002-1205-2356)
- Julio Bobes (ORCID: https://orcid.org/0000-0003-2187-4033)
- Alexander Richards (ORCID: https://orcid.org/0000-0003-3218-7247)
- Marta Di Forti (ORCID: https://orcid.org/0000-0002-3218-6925)
- Lieuwe de Haan
- Pierre-Michel Llorca
- Jean‐Paul Selten
Institutions
- University of Verona (IT)
- University Medical Center Groningen (NL)
- Inserm (FR)
- Universidad de Oviedo (ES)
- King's College London (GB)
- Utrecht University (NL)
- Université Clermont Auvergne (FR)
- University of Cambridge (GB)
- North East London NHS Foundation Trust (GB)
- Maastricht University Medical Centre (NL)
- Hospital General Universitario Gregorio Marañón (ES)
- University Medical Center Utrecht (NL)
- GGZ Noord-Holland-Noord (NL)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Istituto S.Anna Crotone (IT)
- GGZ Rivierduinen (NL)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Amsterdam University Medical Centers (NL)
- Hospital Universitario Virgen del Rocío (ES)
- Medical Research Network (US)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
- University College London (GB)
- Universitat de Barcelona (ES)
- Universidad de Sevilla (ES)
- Cardiff University (GB)
- University of Amsterdam (NL)
- University of Hong Kong (HK)
- University of Palermo (IT)
- University of Bologna (IT)
- University of Lausanne (CH)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/schbul/sbae207
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- National Institute for Health and Care Research
- Leverhulme Trust
- Department of Health and Social Care
- King's College London
- Ministerio de Ciencia e Innovación
- Medical Research Council
- Instituto de Salud Carlos III