Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study

Our study supports an independent role of genetic liability and polyenvironmental risk for psychosis, consistent with the liability threshold model. Whereas schizophrenia-spectrum disorders seem to be mostly associated with polygenic risk for schizophrenia, having an additive effect with well-replicated environmental factors, affective psychosis seems to be a product of cumulative environmental insults alongside a higher genetic liability for affective disorders.

Authors

Institutions

Publication Details

Journal
Schizophrenia Bulletin
Published
2024-12-10
DOI
https://doi.org/10.1093/schbul/sbae207
Citations
5
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
2.75

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study

Celso Arango, Stéphane Jamain, Ilaria Tarricone, Daniele La Barbera et al.
5 citations
Schizophrenia Bulletin
Genetic Associations and Epidemiology
2.75
article

Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study

Celso Arango, Stéphane Jamain, Ilaria Tarricone, Daniele La Barbera, Pak C. Sham, Luis Alameda, Simona A. Stilo, Diego Quattrone, Jim van Os, Miquel Bernardo, Giada Tripoli, Robin M. Murray, Bart P. F. Rutten, James B. Kirkbride, Craig Morgan, Manuel Arrojo, Michael O’Donovan, Caterina La Cascia, Eva Velthorst, Elena Bonora, Charlotte Gayer‐Anderson, Peter Brian Jones, Victoria Rodríguez, Evangelos Vassos, Monica Aas, Giulia Trotta, Edoardo Spinazzola, Antonio Lasalvia, Hannah E. Jongsma, Sarah Tosato, Laura Ferraro, Julio Bobes, Alexander Richards, Marta Di Forti, Lieuwe de Haan, Pierre-Michel Llorca, Jean‐Paul Selten
article en
5 citations

Abstract

Our study supports an independent role of genetic liability and polyenvironmental risk for psychosis, consistent with the liability threshold model. Whereas schizophrenia-spectrum disorders seem to be mostly associated with polygenic risk for schizophrenia, having an additive effect with well-replicated environmental factors, affective psychosis seems to be a product of cumulative environmental insults alongside a higher genetic liability for affective disorders.

Schizophrenia BulletinVol. 51(5)
University of Verona (IT), University Medical Center Groningen (NL), Inserm (FR), Universidad de Oviedo (ES), King's College London (GB), Utrecht University (NL), Université Clermont Auvergne (FR), University of Cambridge (GB), North East London NHS Foundation Trust (GB), Maastricht University Medical Centre (NL), Hospital General Universitario Gregorio Marañón (ES), University Medical Center Utrecht (NL), GGZ Noord-Holland-Noord (NL), Centro de Investigación Biomédica en Red de Salud Mental (ES), Complejo Hospitalario Universitario de Santiago (ES), Istituto S.Anna Crotone (IT), GGZ Rivierduinen (NL), Cambridgeshire and Peterborough NHS Foundation Trust (GB), Instituto de Investigación Sanitaria de Santiago (ES), Amsterdam University Medical Centers (NL), Hospital Universitario Virgen del Rocío (ES), Medical Research Network (US), Instituto de Investigación Sanitaria del Principado de Asturias (ES), University College London (GB), Universitat de Barcelona (ES), Universidad de Sevilla (ES), Cardiff University (GB), University of Amsterdam (NL), University of Hong Kong (HK), University of Palermo (IT), University of Bologna (IT), University of Lausanne (CH)
National Institute for Health and Care Research, Leverhulme Trust, Department of Health and Social Care, King's College London, Ministerio de Ciencia e Innovación, Medical Research Council, Instituto de Salud Carlos III
Openalex Percentile: Top 9%
Genetic Associations and Epidemiology
2.75
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.