Engraftment of self-renewing endometrial epithelial organoids promotes endometrial regeneration by differentiating into functional glands in rats
EEOs offer a transformative approach to address the challenges of endometrial trauma. Their remarkable regenerative potential holds promise for the restoration of damaged endometrium. As we venture into the future, the concept of utilizing patient-specific EEOs for transplantation emerges as a tantalizing prospect. However, the EEOs in our experiments were mainly cultured in Matrigel, which has barriers to clinical translation as a biomaterial, a new biomaterial to be explored. Secondly, our experiments have been successful only in rat models, and more efforts need to be made before clinical translation.
Authors
- Lingyan Zhang
- Xin Ping Xu (ORCID: https://orcid.org/0000-0002-6324-5211)
- Xiaona Lin
- Si‐Jia Chen (ORCID: https://orcid.org/0000-0002-4081-0134)
- Jingjing Qian (ORCID: https://orcid.org/0000-0001-8586-8113)
- Minyuan Wang (ORCID: https://orcid.org/0000-0002-7566-590X)
- Peipei Zhang (ORCID: https://orcid.org/0000-0001-9070-9328)
- Yanling Zhang (ORCID: https://orcid.org/0000-0002-7327-8631)
- Mengying Liu (ORCID: https://orcid.org/0009-0009-6447-9755)
- Cheng Wei
- Yanpeng Wang (ORCID: https://orcid.org/0000-0003-3519-3773)
- Wenzhi Xu (ORCID: https://orcid.org/0000-0002-7554-1739)
- Yana Ma
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- The First People's Hospital of Wenling (CN)
- Hangzhou Medical College (CN)
- Yuxian People's Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fbioe.2024.1449955
- Citations
- 2
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province