TLS and immune cell profiling: immunomodulatory effects of immunochemotherapy on tumor microenvironment in resectable stage III NSCLC
Immunochemotherapy and chemotherapy increase TLSs and granzyme B+ CD8+ T cells in tumors. The TLS area-to-tumor ratio distinguishes responders from non-responders, with PD-L1+ dendritic cells near CD8+PD-1+ T cells linked to efficacy, suggesting that PD-1 inhibitors disrupt harmful interactions. Post-immunochemotherapy, CD8+ T cells increase, but CD38+CD8+ T cells show reduced functionality. These findings highlight the complex immune dynamics and their implications for NSCLC treatment.
Authors
- Jinqi You
- Yan Tang (ORCID: https://orcid.org/0000-0002-6223-8423)
- Ze-Rui Zhao (ORCID: https://orcid.org/0000-0001-9911-9965)
- Jianchuan Xia (ORCID: https://orcid.org/0000-0002-2768-7151)
- Haoran Zhong
- Tong Xiang (ORCID: https://orcid.org/0000-0002-5286-587X)
- Hao Long (ORCID: https://orcid.org/0000-0001-5623-9799)
- Si Chen (ORCID: https://orcid.org/0000-0003-3415-0974)
- Hao Chen (ORCID: https://orcid.org/0009-0006-7836-0091)
- Chaopin Yang (ORCID: https://orcid.org/0000-0003-2724-9247)
- Yizhi Wang (ORCID: https://orcid.org/0009-0008-1449-8424)
- Runfei Song (ORCID: https://orcid.org/0009-0003-5217-0554)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1499731
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Sun Yat-sen University
- China Postdoctoral Science Foundation
- Sun Yat-sen University Cancer Center