Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation
GCH1 is a critical prognostic factor for ESCC and plays a significant role in the regulation of cell proliferation and ferroptosis. Targeting GCH1 in combination with GPX4 and FSP1 inhibitors may offer a novel therapeutic strategy for overcoming resistance in ESCC. Further studies are warranted to elucidate the involved molecular mechanisms and validate these findings <i>in vivo</i>.
Authors
- Masanori Tokunaga (ORCID: https://orcid.org/0000-0002-3183-349X)
- Masanobu Kitagawa (ORCID: https://orcid.org/0000-0002-8538-4837)
- Asuka Furukawa
- Sachiko Ishibashi (ORCID: https://orcid.org/0000-0002-6211-0024)
- Masumi Ikeda (ORCID: https://orcid.org/0000-0002-9296-8187)
- Yusuke Kinugasa (ORCID: https://orcid.org/0000-0002-7885-2276)
- Kurara Yamamoto (ORCID: https://orcid.org/0000-0002-5272-6458)
- Kouhei Yamamoto (ORCID: https://orcid.org/0000-0003-3883-4353)
- Kenichi Ohashi (ORCID: https://orcid.org/0000-0003-1836-1763)
- Masayoshi Sakano
- Shigeo Haruki
- M. Kinoshita (ORCID: https://orcid.org/0000-0001-8900-7951)
- Morito Kurata (ORCID: https://orcid.org/0000-0002-1242-6709)
- Yuki Kato (ORCID: https://orcid.org/0009-0002-4014-2188)
- Y Tomita
- T Kanazawa
- Hiroo OSHITA
- Yuri Hananoi
Institutions
- Tokyo Medical and Dental University (JP)
- Bunkyo Gakuin University (JP)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fonc.2024.1459940
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Ministry of Education, Culture, Sports, Science and Technology