Fibroblast Growth Factor Receptor 4 Promotes Triple‐Negative Breast Cancer Progression via Regulating Fatty Acid Metabolism Through the AKT/RYR2 Signaling
Dysregulated FGFR4 activates the AKT/RYR2 axis, leading to tumor proliferation, invasion, and altered lipid metabolism in TNBC. FGFR4 inhibition could potentially serve as a novel therapeutic strategy for TNBC treatment.
Authors
- Qiang Quan
- Jinhui Ye
- Jianfu Zhao (ORCID: https://orcid.org/0000-0002-6693-2594)
- Cailu Song (ORCID: https://orcid.org/0000-0001-5635-4930)
- Song Wu (ORCID: https://orcid.org/0000-0003-3504-1630)
- Hailin Tang (ORCID: https://orcid.org/0000-0002-3206-782X)
- Huijiao Cao (ORCID: https://orcid.org/0009-0000-7858-1480)
- Yidan Fan
- Feng Ye (ORCID: https://orcid.org/0000-0001-9029-1574)
- Jinhui Zhang (ORCID: https://orcid.org/0000-0002-2677-4480)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- The First People's Hospital of Zhaoqing (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/cam4.70439
- Citations
- 22
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province