A Comparative Study of Nalbuphine, Clonidine, and Dexmedetomidine as Adjuvants to Ropivacaine in Epidural Anesthesia for Lower Limb Surgery

We concluded that the use of dexmedetomidine as an adjuvant to the local anaesthetic agent during epidural block hastens the onset of sensory and motor blockade, provides a longer duration of sensory and motor block, provides longer duration of analgesia, and decreases the total analgesic requirement without causing clinically significant and unmanageable side effects as compared to nalbuphine followed by clonidine.