Interplay Between Serum Apelin, Insulin Resistance and Body Mass Index in Patients with Non-Alcoholic Fatty Liver Disease: A Comparative Analysis

Introduction: Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver disease, particularly among individuals with high BMI.Apelin, a bioactive peptide known for its involvement in metabolic processes, has emerged as a significant player in the pathogenesis of NAFLD.The present study explores the role of apelin in the development and progression of NAFLD in individuals with high body mass index (BMI), examining its potential as a biomarker.This study highlights the mechanisms through which apelin modulates insulin resistance (IR), lipid metabolism and development of NAFLD and to measure serum apelin and IR in patients with and without NAFLD and to investigate the correlation between these parameters and establish whether apelin can be used as a biomarker of NAFLD.Materials and Methods: It was a cross-sectional study, conducted at the Post-graduate Dept. of Biochemistry in collaboration with the Dept. of General Medicine, SCB Medical College, Cuttack from October 2018 to