Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice
The deficiency in V1 receptor genes may increase gut butyric acid levels and impair the function of L cells, thus dysregulating lipid homeostasis in the brown adipose tissue and skeletal muscle. This study highlights the importance of appropriate control of the gut microbiota and its metabolites, including butyric acid, for the optimum functioning of enteroendocrine cells.
Authors
- Masao Miyazaki (ORCID: https://orcid.org/0000-0003-2579-1788)
- Fumihiko Maekawa (ORCID: https://orcid.org/0000-0002-1762-8270)
- Yukiko Hayashi (ORCID: https://orcid.org/0000-0003-4043-1756)
- Yuri Osuga
- Kie Shimizu (ORCID: https://orcid.org/0009-0008-3716-9279)
- Masami Yokota Hirai (ORCID: https://orcid.org/0000-0003-0802-6208)
- Reiko Uenoyama (ORCID: https://orcid.org/0000-0001-9001-9853)
- Takashi Tsuboi (ORCID: https://orcid.org/0000-0001-8290-2021)
- E. Wada (ORCID: https://orcid.org/0000-0002-9139-9621)
- Kazuki Harada (ORCID: https://orcid.org/0000-0002-0793-6851)
- Kazuaki Nakamura (ORCID: https://orcid.org/0000-0003-4999-5056)
Institutions
- Tokyo Medical University (JP)
- Iwate University (JP)
- National Institute for Environmental Studies (JP)
- RIKEN Center for Sustainable Resource Science (JP)
- Saitama University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.molmet.2024.102072
- Citations
- 2
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- University of Tokyo
- National Center of Neurology and Psychiatry
- Servier
- Japan Society for the Promotion of Science
- RIKEN