Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling

These results suggest that CPB-like sheared monocytes promote IL-8 production followed by increased endothelium permeability, and monocyte adhesion and transmigration. This study revealed a novel mechanism of post-CPB inflammation and will contribute to the development of targeted therapeutics to prevent and repair the damage to neonatal patients.

Authors

Cecilia M. Giachelli (ORCID: https://orcid.org/0000-0002-6387-5993)
Marta Scatena (ORCID: https://orcid.org/0000-0002-2288-6020)
Lan N. Tu (ORCID: https://orcid.org/0000-0002-6362-8554)
Vishal Nigam (ORCID: https://orcid.org/0000-0002-9652-8146)
Hao Zhou (ORCID: https://orcid.org/0000-0002-6904-607X)

Institutions

Seattle Children's Hospital (US)
University of Washington (US)

Publication Details

Journal: Frontiers in Cardiovascular Medicine
Published: 2024-12-11
DOI: https://doi.org/10.3389/fcvm.2024.1454302
Citations: 1
Primary Topic: Cardiac and Coronary Surgery Techniques
Type: article
Field-Weighted Citation Impact: 0.57

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article

Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling

Cecilia M. Giachelli, Marta Scatena, Lan N. Tu, Vishal Nigam et al.

Dec 11, 2024

1 citations

Frontiers in Cardiovascular Medicine

Cardiac and Coronary Surgery Techniques

0.57

article

Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling

Cecilia M. Giachelli, Marta Scatena, Lan N. Tu, Vishal Nigam, Hao Zhou

December 11, 2024article en

1 citations

Abstract

These results suggest that CPB-like sheared monocytes promote IL-8 production followed by increased endothelium permeability, and monocyte adhesion and transmigration. This study revealed a novel mechanism of post-CPB inflammation and will contribute to the development of targeted therapeutics to prevent and repair the damage to neonatal patients.

Frontiers in Cardiovascular MedicineVol. 11

Seattle Children's Hospital (US), University of Washington (US)

Good health and well-being

Openalex Percentile: Top 27%

Cardiac and Coronary Surgery Techniques

0.57

DOI Open Access PDF OpenAlex

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