Evidence of compensatory neural hyperactivity in a subgroup of breast cancer survivors treated with chemotherapy and its association with brain aging
Our results indicated that neural hyperactivity is specific to a subgroup of breast cancer survivors and, while it seems to support preserved cognitive function, it could also increase the risk of accelerated brain aging. These findings could inform future neuromodulatory interventions with respect to the risks and benefits of upregulation or downregulation of neural activity.
Authors
- Michele M. Mulholland (ORCID: https://orcid.org/0000-0003-1957-0436)
- Shelli R. Kesler (ORCID: https://orcid.org/0000-0002-0515-7942)
- Alexa De La Torre Schutz (ORCID: https://orcid.org/0009-0008-2572-1783)
- Douglas W. Blayney (ORCID: https://orcid.org/0000-0002-7931-4533)
- Alexa Stuifbergen (ORCID: https://orcid.org/0000-0003-1609-4040)
- Oscar Y. Franco Rocha
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas at Austin (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fnagi.2024.1421703
- Citations
- 2
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84