Sex dependent correlation of spleen atrophy and behavior deficits induced by binge treatment with ethanol in rodent models
Using data-driven discovery and hypothesis-testing investigation to integrate these two studies, we provide an understanding of the underlying biological mechanism of BE-induced spleen atrophy-associated behavioral impairments through the genetic alterations in the PFC. Our findings will help develop a potent, powerful cocktail of reagents to treat behavioral impairment in those who binge drink.
Authors
- Sulie L. Chang (ORCID: https://orcid.org/0000-0003-3865-4280)
- Muhammed Bishir (ORCID: https://orcid.org/0000-0001-8883-3186)
- Jonathan Zhang (ORCID: https://orcid.org/0009-0002-4646-4938)
- Wenfei Huang (ORCID: https://orcid.org/0000-0003-4506-8052)
Institutions
- Seton Hall University (US)
Publication Details
- Journal
- NeuroImmune Pharmacology and Therapeutics
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1515/nipt-2024-0016
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Alcohol Abuse and Alcoholism