Analgesic effect of Dahuang Fuzi Decoction in neuropathic pain through inhibiting TNF-α and PI3K-AKT signaling
Our findings characterize the chemical constituents of DF and elucidate its underlying mechanism for relieving NeP. The analgesic effect of DF involves the inhibition of TNF-α and PI3K-AKT signaling pathways, providing a potential therapeutic approach for NeP management.
Authors
- Jinglian Qu
- Peng Chen (ORCID: https://orcid.org/0000-0001-5168-448X)
- Qian Gong
- Peng Jin (ORCID: https://orcid.org/0000-0001-5095-5743)
- Siyu He (ORCID: https://orcid.org/0000-0003-1137-2291)
- Long Wang (ORCID: https://orcid.org/0000-0002-4547-2736)
- Lingyan Chen (ORCID: https://orcid.org/0000-0003-3750-6761)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Southwest Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fnins.2024.1464477
- Citations
- 3
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- National Natural Science Foundation of China
- Fudan University