Proteomic analysis of the Treponema pallidum subsp. pallidum SS14 strain: coverage and comparison with the Nichols strain proteome
This study provides the first comparative analyses of the proteomes from the <i>T. pallidum</i> SS14 and Nichols strains. The findings inform syphilis vaccine design by confirming the expression of known/predicted OMP vaccine candidates in SS14 treponemes, and via the finding that most inter-strain variable residues found in OMPs are predicted to be located in surface-exposed, host-facing regions of these proteins.
Authors
- Caroline E. Cameron (ORCID: https://orcid.org/0000-0002-8786-4359)
- Steven H. Marshall (ORCID: https://orcid.org/0009-0003-1811-2633)
- Simon Houston (ORCID: https://orcid.org/0000-0001-5961-5227)
- Alloysius Gomez
Institutions
- University of Washington (US)
- University of Victoria (CA)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fmicb.2024.1505893
- Citations
- 1
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- University of Washington
- Open Philanthropy Project
- Genome British Columbia
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases