Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells
Linsitinib effectively induces apoptosis and inhibits proliferation of both IGF-1R and TSH-R expressing target cells, therefore demonstrating its therapeutic potential to block the reported crosstalk of the two mediators in autoimmune TED.
Authors
- Jan Wolf
- Jeffrey D. Kent
- Ryan K. Zeidan
- Raymond S. Douglas (ORCID: https://orcid.org/0000-0002-3435-8161)
- George J. Kahaly (ORCID: https://orcid.org/0000-0003-0441-430X)
- Stefanie Wagner (ORCID: https://orcid.org/0000-0002-3873-7011)
- Maximilian Luffy
- Julian Ropertz
- Anna-Lena Ganz
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fimmu.2024.1488220
- Citations
- 9
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.82