Probiotic effects of human milk‐derived <i>Lactiplantibacillus plantarum</i> M660 on mice with antibiotic‐associated diarrhoea and constipation
Lactiplantibacillus plantarum M660 (M660) was isolated from the human milk of a healthy mother. M660 could survive the simulated gastrointestinal conditions without haemolytic and biogenic amine‐producing ability. The faecal water content was reduced, and the recoveries of the cecum and intestinal barrier were accelerated by M660 in the antibiotic‐associated diarrhoea model. In the constipation model, M660 enhanced intestinal motility, improved serum neurotransmitter levels, and reduced colonic injury. Analysis of gut microbiota showed that M660 increased the abundance of potentially beneficial bacteria and decreased the number of potentially pathogenic bacteria. Overall, M660 could be a probiotic candidate to promote infant health.
Authors
- Junjuan Yu
- Rongxue Tang
- Ruixia Gu (ORCID: https://orcid.org/0000-0002-6186-4318)
- Yujun Huang (ORCID: https://orcid.org/0000-0002-2763-6776)
- Hengxian Qu (ORCID: https://orcid.org/0000-0002-5802-8650)
- Yunchao Wa (ORCID: https://orcid.org/0000-0002-5437-0483)
- Jiaqi Wang (ORCID: https://orcid.org/0000-0001-8841-0124)
- Chenchen Zhang (ORCID: https://orcid.org/0000-0001-8563-5002)
- Lina Pan (ORCID: https://orcid.org/0000-0001-8839-2923)
- Xia Chen (ORCID: https://orcid.org/0000-0002-7222-1166)
- Wenli Kang (ORCID: https://orcid.org/0000-0002-7345-5079)
- Dandan Li (ORCID: https://orcid.org/0000-0002-9753-2331)
- Haodong Yan
Institutions
- Hunan Agricultural Products (China) (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- International Journal of Dairy Technology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1111/1471-0307.13159
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China