An Important Adipokine: Isthmin-1

The presence of isthmin-1 in different body compartments reveals its significance in metabolism, cell proliferation, endothelial permeability, angiogenesis and immunity. Studies have categorized isthmin-1 as an adipokine with insulin-like behavior that uptakes glucose by the adipocytes and inhibits liver steatosis through a not identified tyrosine kinase receptor, that it is distinct from insulin receptor. Additionally, this adipokine demonstrates important functions in regulating organs development and homeostasis. This review aims to summarize the informations of isthmin-1 protein mainly its functions on glucose and lipid metabolisms.